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Evaluation of Plasma IL-6 in Patients with Melanoma as a Prognostic and Checkpoint Immunotherapy Predictive Biomarker

Yuling Wang, Vijaya Ramachandran, Dawen Sui, Kejing Xu, Lauren Elaine Haydu, Shenying Fang, Jennifer Leigh McQuade, Sarah B. Fisher, Anthony Lucci, Emily Zhi-Yun Keung, Jennifer Ann Wargo, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey E. Lee

Journal of Investigative Dermatology · 2021 · ▲ 23 citations

Chronic inflammation Human

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Abstract

Treatment of advanced melanoma has been revolutionized by targeted therapy (TT) and immune checkpoint blockade (ICB), but not all patients respond; identification of predictive biomarkers remains a critical need. Our previous investigations showed the circulating level of CRP as an independent melanoma prognostic biomarker (Fang et al., 2017, 2016, 2015). IL-6 is upstream of CRP, induces hepatocyte release of CRP, and is a pleiotropic inflammatory cytokine involved in progression of melanoma (Hoejberg et al., 2012).

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Provenance

Source: OpenAlex
DOI: 10.1016/j.jid.2021.12.012
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Fetched: 2026-10-16 MST

Cite this

APA

Wang, Y., Ramachandran, V., Sui, D., Xu, K., Haydu, L.E., Fang, S., McQuade, J.L., Fisher, S.B., Lucci, A., Keung, E.Z., Wargo, J.A., Gershenwald, J.E., Ross, M.I., & Lee, J.E. (2021). Evaluation of Plasma IL-6 in Patients with Melanoma as a Prognostic and Checkpoint Immunotherapy Predictive Biomarker. <em>Journal of Investigative Dermatology</em>. https://doi.org/10.1016/j.jid.2021.12.012

Vancouver

Wang Y, Ramachandran V, Sui D, Xu K, Haydu LE, Fang S, et al. Evaluation of Plasma IL-6 in Patients with Melanoma as a Prognostic and Checkpoint Immunotherapy Predictive Biomarker. Journal of Investigative Dermatology. 2021. doi:10.1016/j.jid.2021.12.012.

BibTeX

@article{yuling2021Evalua, title = {Evaluation of Plasma IL-6 in Patients with Melanoma as a Prognostic and Checkpoint Immunotherapy Predictive Biomarker}, author = {Yuling Wang and Vijaya Ramachandran and Dawen Sui and Kejing Xu and Lauren Elaine Haydu and Shenying Fang and Jennifer Leigh McQuade and Sarah B. Fisher and Anthony Lucci and Emily Zhi-Yun Keung and Jennifer Ann Wargo and Jeffrey E. Gershenwald and Merrick I. Ross and Jeffrey E. Lee}, journal = {Journal of Investigative Dermatology}, year = {2021}, doi = {10.1016/j.jid.2021.12.012}, }