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Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Madhulika Tripathi, Paul M. Yen, Brijesh Kumar Singh

International Journal of Molecular Sciences · 2020 · ▲ 99 citations

Mitochondrial dysfunction Disabled macroautophagy Review

Abstract

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

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Provenance

Source: OpenAlex
DOI: 10.3390/ijms21051645
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Fetched: 2026-06-06 MST

Cite this

APA

Tripathi, M., Yen, P.M., & Singh, B.K. (2020). Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. <em>International Journal of Molecular Sciences</em>. https://doi.org/10.3390/ijms21051645

Vancouver

Tripathi M, Yen PM, Singh BK. Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. International Journal of Molecular Sciences. 2020. doi:10.3390/ijms21051645.

BibTeX

@article{madhulika2020Estrog, title = {Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases}, author = {Madhulika Tripathi and Paul M. Yen and Brijesh Kumar Singh}, journal = {International Journal of Molecular Sciences}, year = {2020}, doi = {10.3390/ijms21051645}, }