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Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)

Anthony Estienne, Alice Bongrani, Christelle Ramé, Patrycja Kurowska, Klaudia Błaszczyk, Agnieszka Rak, Pierre‐Henri Ducluzeau, Pascal Froment, Joëlle Dupont

Molecular and Cellular Endocrinology · 2020 · ▲ 45 citations

Deregulated nutrient-sensing Altered intercellular communication Rapamycin / mTOR inhibition Review

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Abstract

In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including the hypothalamic GnRH neuronal network, the pituitary gonadotropin secretion and the ovarian follicle growth and steroidogenesis. Several hormones and neuropeptides or metabolites are important signals between energy balance and reproduction. These energy sensors mediate their action on reproductive cells through specific kinases or signaling pathways. This review focuses on the role of three main enzymes-specifically, mTOR, AMPK, and SIRT1 at the hypothalamic pituitary and ovarian axis in normal female fertility and then we discuss their possible involvement in some women reproductive disorders known to be associated with metabolic complications, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF).

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Provenance

Source: OpenAlex
DOI: 10.1016/j.mce.2020.111113
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Fetched: 2026-09-25 MST

Cite this

APA

Estienne, A., Bongrani, A., Ramé, C., Kurowska, P., Błaszczyk, K., Rak, A., Ducluzeau, P., Froment, P., & Dupont, J. (2020). Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1). <em>Molecular and Cellular Endocrinology</em>. https://doi.org/10.1016/j.mce.2020.111113

Vancouver

Estienne A, Bongrani A, Ramé C, Kurowska P, Błaszczyk K, Rak A, et al. Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1). Molecular and Cellular Endocrinology. 2020. doi:10.1016/j.mce.2020.111113.

BibTeX

@article{anthony2020Energy, title = {Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)}, author = {Anthony Estienne and Alice Bongrani and Christelle Ramé and Patrycja Kurowska and Klaudia Błaszczyk and Agnieszka Rak and Pierre‐Henri Ducluzeau and Pascal Froment and Joëlle Dupont}, journal = {Molecular and Cellular Endocrinology}, year = {2020}, doi = {10.1016/j.mce.2020.111113}, }