Effect of metformin on mitochondrial function of glioma cells

Metformin is a classic treatment for diabetes. In recent years, metformin has been shown to inhibit the growth of tumour cells in vitro and in vivo and to increase the sensitivity of radiotherapy and chemotherapy. This study investigated the effects of metformin on active clonogenic energy and mitochondrial function in human glioma cells U87 and U251 to provide effective data for further understanding the mechanism of metformin in the treatment of glioma. To investigate the effect of metformin on mitochondrial function in U87 and U251 glioma cells. The changes in mitochondrial membrane potential, reactive oxygen species (ROS) and oxygen consumption and respiration in U87 and U251 human glioma cells treated with metformin were determined.