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Do we actually need aging clocks?

Dmitrii V. Kriukov, Evgeniy Efimov, Mikhail Sergeevich Gelfand, Alexey Moskalev, Ekaterina E. Khrameeva

npj Aging · 2025 · ▲ 9 citations

Abstract

Aging clocks use machine learning to estimate biological age as a proxy for general health state. Here, we critically examine their practical value, highlighting fundamental challenges: abstract definitions, inconsistent clinical validation, and ignored prediction uncertainty. By comparing aging clocks with expert risk scores, direct outcome predictors, and emerging large health models, we question their benefits and encourage researchers to explicitly justify clock advantage over established alternatives, ensuring truly actionable insights.

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Provenance

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OpenAlex
DOI
10.1038/s41514-025-00312-2
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2026-10-14 MST

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APA
Kriukov, D.V., Efimov, E., Gelfand, M.S., Moskalev, A., &amp; Khrameeva, E.E. (2025). Do we actually need aging clocks?. <em>npj Aging</em>. https://doi.org/10.1038/s41514-025-00312-2
Vancouver
Kriukov DV, Efimov E, Gelfand MS, Moskalev A, Khrameeva EE. Do we actually need aging clocks?. npj Aging. 2025. doi:10.1038/s41514-025-00312-2.
BibTeX
@article{dmitrii2025Doweac, title = {Do we actually need aging clocks?}, author = {Dmitrii V. Kriukov and Evgeniy Efimov and Mikhail Sergeevich Gelfand and Alexey Moskalev and Ekaterina E. Khrameeva}, journal = {npj Aging}, year = {2025}, doi = {10.1038/s41514-025-00312-2}, }

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