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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

WHI-EMPC Investigators, Symen Ligthart, CHARGE epigenetics of Coronary Heart Disease, Carola Marzi, Stella Aslibekyan, Michael Mendelson, Karen N. Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L. Waite, Roby Joehanes, Weihua Guan, Jennifer A. Brody, Cathy E. Elks, Riccardo E. Marioni

Genome biology · 2016 · ▲ 338 citations

Abstract

BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. RESULTS: ). An additive weighted score of replicated CpG sites accounted for up to 6% inter-individual variation (R2) of age-adjusted and sex-adjusted CRP, independent of known CRP-related genetic variants. CONCLUSION: We have completed an EWAS of chronic low-grade inflammation and identified many novel genetic loci underlying inflammation that may serve as targets for the development of novel therapeutic interventions for inflammation.

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OpenAlex
DOI
10.1186/s13059-016-1119-5
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2026-06-09 MST

Cite this

APA
Investigators, W., Ligthart, S., Disease, C.E.O.C.H., Marzi, C., Aslibekyan, S., Mendelson, M., Conneely, K.N., Tanaka, T., Colicino, E., Waite, L.L., Joehanes, R., Guan, W., Brody, J.A., Elks, C.E., Marioni, R.E., Jhun, M.A., Agha, G., Bressler, J., Ward‐Caviness, C., &amp; Chen, B.H. (2016). DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. <em>Genome biology</em>. https://doi.org/10.1186/s13059-016-1119-5
Vancouver
Investigators W, Ligthart S, Disease CEOCH, Marzi C, Aslibekyan S, Mendelson M, et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome biology. 2016. doi:10.1186/s13059-016-1119-5.
BibTeX
@article{whiempc2016DNAmet, title = {DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases}, author = {WHI-EMPC Investigators and Symen Ligthart and CHARGE epigenetics of Coronary Heart Disease and Carola Marzi and Stella Aslibekyan and Michael Mendelson and Karen N. Conneely and Toshiko Tanaka and Elena Colicino and Lindsay L. Waite and Roby Joehanes and Weihua Guan and Jennifer A. Brody and Cathy E. Elks and Riccardo E. Marioni and Min A. Jhun and Golareh Agha and Jan Bressler and Cavin Ward‐Caviness and Brian H. Chen and Tianxiao Huan and Kelly M. Bakulski and Elias Salfati and Giovanni Fiorito and Simone Wahl}, journal = {Genome biology}, year = {2016}, doi = {10.1186/s13059-016-1119-5}, }

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