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DNA methylation in early development

Molecular Reproduction and Development · 2009 · ▲ 132 citations

Epigenetic alterations Stem-cell exhaustion Review

Abstract

Development from separate parental germ cells through fertilization and proceeding to a fully functioning adult animal occurs through an intricate program of transcriptional and chromatin changes. Epigenetic alterations such as DNA methylation are an important part of this process. This review looks at the role of DNA methylation in early embryonic development, as well as how this epigenetic mark affects stem cell differentiation and tissue-specific gene expression in somatic cells.

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Provenance

Source: OpenAlex
DOI: 10.1002/mrd.21118
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Fetched: 2026-09-29 MST

Cite this

APA

Geiman, T.M., & Muegge, K. (2009). DNA methylation in early development. <em>Molecular Reproduction and Development</em>. https://doi.org/10.1002/mrd.21118

Vancouver

Geiman TM, Muegge K. DNA methylation in early development. Molecular Reproduction and Development. 2009. doi:10.1002/mrd.21118.

BibTeX

@article{theresa2009DNAmet, title = {DNA methylation in early development}, author = {Theresa M. Geiman and Kathrin Muegge}, journal = {Molecular Reproduction and Development}, year = {2009}, doi = {10.1002/mrd.21118}, }