DNA METHYLATION: CAUSE OR CONSEQUENCE OF AGING?

Abstract Epigenetic changes are one of the telomere(definition) attrition, cellular senescence(definition))." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">Hallmarks of Aging(definition). DNA methylation is a key epigenetic mark that has been shown to change during aging. Several "clocks" have been developed whereby changes in DNA methylation can be used to predict chronological, and perhaps, biological age. This symposium will focus on recent advances in understanding how and why changes in DNA methylation occur during aging and whether these changes play a causal role in age-related functional declines and disease.