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Aging and DNA methylation

BMC Biology · 2015 · ▲ 569 citations

Epigenetic alterations

Abstract

In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.

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Provenance

Source: OpenAlex
DOI: 10.1186/s12915-015-0118-4
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Fetched: 2026-06-12 MST

Cite this

APA

Jung, M., & Pfeifer, G.P. (2015). Aging and DNA methylation. <em>BMC Biology</em>. https://doi.org/10.1186/s12915-015-0118-4

Vancouver

Jung M, Pfeifer GP. Aging and DNA methylation. BMC Biology. 2015. doi:10.1186/s12915-015-0118-4.

BibTeX

@article{marc2015Aginga, title = {Aging and DNA methylation}, author = {Marc Jung and Gerd P. Pfeifer}, journal = {BMC Biology}, year = {2015}, doi = {10.1186/s12915-015-0118-4}, }