Open access · OA via OpenAlex

DNA damage and repair in atherosclerosis

M Mahmoudi, Julian G. Mercer, Martin R. Bennett

Cardiovascular Research · 2006 · ▲ 138 citations

Genomic instability Mitochondrial dysfunction Cellular senescence Human Review

Abstract

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1016/j.cardiores.2006.03.002
Canonical: link ↗
Fetched: 2026-06-09 MST

Cite this

APA

Mahmoudi, M., Mercer, J.G., & Bennett, M.R. (2006). DNA damage and repair in atherosclerosis. <em>Cardiovascular Research</em>. https://doi.org/10.1016/j.cardiores.2006.03.002

Vancouver

Mahmoudi M, Mercer JG, Bennett MR. DNA damage and repair in atherosclerosis. Cardiovascular Research. 2006. doi:10.1016/j.cardiores.2006.03.002.

BibTeX

@article{m2006DNAdam, title = {DNA damage and repair in atherosclerosis}, author = {M Mahmoudi and Julian G. Mercer and Martin R. Bennett}, journal = {Cardiovascular Research}, year = {2006}, doi = {10.1016/j.cardiores.2006.03.002}, }