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Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization

Natalie Tabor, Conelius Ngwa, Jérémie Mitteaux, Matthew D. Meyer, Jose F. Moruno-Manchon, Liang Zhu, Fudong Liu, David Monchaud, Louise D. McCullough, Andrey S. Tsvetkov

Aging · 2021 · ▲ 21 citations

Genomic instability Cellular senescence

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Abstract

in astrocytes and microglia, indicating differences in DNA damage and repair pathways between brain cell types. Taken together, our findings suggest that stabilized G4-DNA contribute to genomic instability in the brain and may represent a novel senescence pathway in brain aging.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.203222
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Fetched: 2026-06-02 MST

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APA

Tabor, N., Ngwa, C., Mitteaux, J., Meyer, M.D., Moruno-Manchon, J.F., Zhu, L., Liu, F., Monchaud, D., McCullough, L.D., & Tsvetkov, A.S. (2021). Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization. <em>Aging</em>. https://doi.org/10.18632/aging.203222

Vancouver

Tabor N, Ngwa C, Mitteaux J, Meyer MD, Moruno-Manchon JF, Zhu L, et al. Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization. Aging. 2021. doi:10.18632/aging.203222.

BibTeX

@article{natalie2021Differ, title = {Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization}, author = {Natalie Tabor and Conelius Ngwa and Jérémie Mitteaux and Matthew D. Meyer and Jose F. Moruno-Manchon and Liang Zhu and Fudong Liu and David Monchaud and Louise D. McCullough and Andrey S. Tsvetkov}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.203222}, }