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Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Christopher A. Wolff, Miguel A. Gutierrez‐Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan Alava, Stuart J. Hesketh, Andrew R. Morris

Cell Reports · 2023 · ▲ 149 citations

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Abstract

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the telomere(definition) attrition, cellular senescence(definition))." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">hallmarks of aging(definition), adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.

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OpenAlex
DOI
10.1016/j.celrep.2022.111982
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2026-07-27 MST

Cite this

APA
Wolff, C.A., Gutierrez‐Monreal, M.A., Meng, L., Zhang, X., Douma, L.G., Costello, H.M., Douglas, C.M., Ebrahimi, E., Pham, A., Oliveira, A.C., Fu, C., Nguyen, A., Alava, B., Hesketh, S.J., Morris, A.R., Endale, M., Crislip, G.R., Cheng, K., Schroder, E.A., &amp; Delisle, B.P. (2023). Defining the age-dependent and tissue-specific circadian transcriptome in male mice. <em>Cell Reports</em>. https://doi.org/10.1016/j.celrep.2022.111982
Vancouver
Wolff CA, Gutierrez‐Monreal MA, Meng L, Zhang X, Douma LG, Costello HM, et al. Defining the age-dependent and tissue-specific circadian transcriptome in male mice. Cell Reports. 2023. doi:10.1016/j.celrep.2022.111982.
BibTeX
@article{christopher2023Defini, title = {Defining the age-dependent and tissue-specific circadian transcriptome in male mice}, author = {Christopher A. Wolff and Miguel A. Gutierrez‐Monreal and Lingsong Meng and Xiping Zhang and Lauren G. Douma and Hannah M. Costello and Collin M. Douglas and Elnaz Ebrahimi and Ann Pham and Aline C. Oliveira and Chunhua Fu and Amy Nguyen and Bryan Alava and Stuart J. Hesketh and Andrew R. Morris and Mehari Endale and G. Ryan Crislip and Kit‐Yan Cheng and Elizabeth A. Schroder and Brian P. Delisle and Andrew J. Bryant and Michelle L. Gumz and Zhiguang Huo and Andrew C. Liu and Karyn A. Esser}, journal = {Cell Reports}, year = {2023}, doi = {10.1016/j.celrep.2022.111982}, }

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