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Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Agnes T. Reiner, Kenneth W. Witwer, Bas W. M. van Balkom, Joel de Beer, Chaya Brodie, Randolph Corteling, Susanne Gabrielsson, Mario Gimona, Ahmed Ibrahim, Dominique P.V. de Kleijn, Charles Pin‐Kuang Lai, Jan Lötvall, Hernando A. del Portillo, Ilona Reischl, Milad Riazifar

Stem Cells Translational Medicine · 2017 · ▲ 350 citations

Stem-cell exhaustion Altered intercellular communication Human Preclinical / animal Review

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Abstract

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730-1739.

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Provenance

Source: OpenAlex
DOI: 10.1002/sctm.17-0055
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Fetched: 2026-06-07 MST

Cite this

APA

Reiner, A.T., Witwer, K.W., Balkom, B.W.M.V., Beer, J.D., Brodie, C., Corteling, R., Gabrielsson, S., Gimona, M., Ibrahim, A., Kleijn, D.P.D., Lai, C.P., Lötvall, J., Portillo, H.A.D., Reischl, I., Riazifar, M., Salomón, C., Tahara, H., Toh, W.S., Wauben, M.H.M., & Yang, V.K. (2017). Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. <em>Stem Cells Translational Medicine</em>. https://doi.org/10.1002/sctm.17-0055

Vancouver

Reiner AT, Witwer KW, Balkom BWMV, Beer JD, Brodie C, Corteling R, et al. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Translational Medicine. 2017. doi:10.1002/sctm.17-0055.

BibTeX

@article{agnes2017Concis, title = {Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles}, author = {Agnes T. Reiner and Kenneth W. Witwer and Bas W. M. van Balkom and Joel de Beer and Chaya Brodie and Randolph Corteling and Susanne Gabrielsson and Mario Gimona and Ahmed Ibrahim and Dominique P.V. de Kleijn and Charles Pin‐Kuang Lai and Jan Lötvall and Hernando A. del Portillo and Ilona Reischl and Milad Riazifar and Carlos Salomón and Hidetoshi Tahara and Wei Seong Toh and Marca H. M. Wauben and Vicky K. Yang and Yijun Yang and Ronne Wee Yeh Yeo and Hang Yin and Bernd Giebel and Eva Rohde}, journal = {Stem Cells Translational Medicine}, year = {2017}, doi = {10.1002/sctm.17-0055}, }