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Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

Alberto Lleó, Raúl Núñez‐Llaves, Daniel Andres Alcolea, Cristina Chiva, Daniel Balateu, Martí Colom‐Cadena, Gemma Gomez‐Giro, Laia Muñoz, Marta Querol‐Vilaseca, Jordi Pegueroles, Lorena Rami, Albert Lladó, José Luís Molinuevo, Mikel Tainta, Jordi Clarimón

Molecular & Cellular Proteomics · 2019 · ▲ 218 citations

Loss of proteostasis Human Preclinical / animal

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Abstract

In BriefIn the search for biomarkers of synapse loss associated with Alzheimer's disease (AD), we used shotgun proteomics to identify a panel of 9 synaptic proteins detectable in human cerebrospinal fluid (CSF).Expression at the human synapse was verified using super resolution microscopy.Using SRM, we monitored the panel in CSF from 3 independent clinical cohorts.We report 6 synaptic biomarkers that demonstrate changes in preclinical AD prior to markers of neurodegeneration, which could have clinical value for assessing disease progression.

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Provenance

Source: OpenAlex
DOI: 10.1074/mcp.ra118.001290
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Fetched: 2026-10-17 MST

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APA

Lleó, A., Núñez‐Llaves, R., Alcolea, D.A., Chiva, C., Balateu, D., Colom‐Cadena, M., Gomez‐Giro, G., Muñoz, L., Querol‐Vilaseca, M., Pegueroles, J., Rami, L., Lladó, A., Molinuevo, J.L., Tainta, M., Clarimón, J., Spires‐Jones, T.L., Blesa, R., Fortea, J., Martínez‐Lage, P., & Sánchez‐Valle, R. (2019). Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid. <em>Molecular & Cellular Proteomics</em>. https://doi.org/10.1074/mcp.ra118.001290

Vancouver

Lleó A, Núñez‐Llaves R, Alcolea DA, Chiva C, Balateu D, Colom‐Cadena M, et al. Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid. Molecular & Cellular Proteomics. 2019. doi:10.1074/mcp.ra118.001290.

BibTeX

@article{alberto2019Change, title = {Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid}, author = {Alberto Lleó and Raúl Núñez‐Llaves and Daniel Andres Alcolea and Cristina Chiva and Daniel Balateu and Martí Colom‐Cadena and Gemma Gomez‐Giro and Laia Muñoz and Marta Querol‐Vilaseca and Jordi Pegueroles and Lorena Rami and Albert Lladó and José Luís Molinuevo and Mikel Tainta and Jordi Clarimón and Tara L. Spires‐Jones and Rafael Blesa and Juan Fortea and Pablo Martínez‐Lage and Raquel Sánchez‐Valle and Eduard Sabidó and Àlex Bayés and Olivia Belbin}, journal = {Molecular & Cellular Proteomics}, year = {2019}, doi = {10.1074/mcp.ra118.001290}, }