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Cellular reprogramming as a tool to model human aging in a dish

Patrícia R. Pitrez, Luís Miguel Monteiro, Oliver Borgogno, Xavier Nissan, Jérôme Mertens, Lino Ferreira

Nature Communications · 2024 · ▲ 48 citations

Stem-cell exhaustion Partial reprogramming (OSK) Human

Abstract

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41467-024-46004-5
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Fetched: 2026-07-08 MST

Cite this

APA

Pitrez, P.R., Monteiro, L.M., Borgogno, O., Nissan, X., Mertens, J., & Ferreira, L. (2024). Cellular reprogramming as a tool to model human aging in a dish. <em>Nature Communications</em>. https://doi.org/10.1038/s41467-024-46004-5

Vancouver

Pitrez PR, Monteiro LM, Borgogno O, Nissan X, Mertens J, Ferreira L. Cellular reprogramming as a tool to model human aging in a dish. Nature Communications. 2024. doi:10.1038/s41467-024-46004-5.

BibTeX

@article{patrcia2024Cellul, title = {Cellular reprogramming as a tool to model human aging in a dish}, author = {Patrícia R. Pitrez and Luís Miguel Monteiro and Oliver Borgogno and Xavier Nissan and Jérôme Mertens and Lino Ferreira}, journal = {Nature Communications}, year = {2024}, doi = {10.1038/s41467-024-46004-5}, }