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Cardiac stem cell niches

Annarosa Leri, Marcello Rota, Toru Hosoda, Polina Goichberg, Piero Anversa

Stem Cell Research · 2014 · ▲ 78 citations

Stem-cell exhaustion Altered intercellular communication Review

Abstract

The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches represent specialized microdomains where the quiescent and activated state of resident stem cells is regulated. Alterations in niche function with aging and cardiac diseases result in abnormal sites of cardiomyogenesis and inadequate myocyte formation. The relevance of Notch1 signaling, gap-junction formation, HIF-1α and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.scr.2014.09.001
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Fetched: 2026-08-03 MST

Cite this

APA

Leri, A., Rota, M., Hosoda, T., Goichberg, P., & Anversa, P. (2014). Cardiac stem cell niches. <em>Stem Cell Research</em>. https://doi.org/10.1016/j.scr.2014.09.001

Vancouver

Leri A, Rota M, Hosoda T, Goichberg P, Anversa P. Cardiac stem cell niches. Stem Cell Research. 2014. doi:10.1016/j.scr.2014.09.001.

BibTeX

@article{annarosa2014Cardia, title = {Cardiac stem cell niches}, author = {Annarosa Leri and Marcello Rota and Toru Hosoda and Polina Goichberg and Piero Anversa}, journal = {Stem Cell Research}, year = {2014}, doi = {10.1016/j.scr.2014.09.001}, }