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Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Hao Cui, Ying Hu, Zin Mei Wang, Hai Bo Tan, Hua Rong, Hong Cui

Clinical Interventions in Aging · 2013 · ▲ 50 citations

Stem-cell exhaustion Stem-cell therapy Rat

Abstract

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

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Provenance

Source: OpenAlex
DOI: 10.2147/cia.s47350
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Fetched: 2026-10-10 MST

Cite this

APA

Cui, H., Hu, Y., Wang, Z.M., Tan, H.B., Rong, H., & Cui, H. (2013). Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma. <em>Clinical Interventions in Aging</em>. https://doi.org/10.2147/cia.s47350

Vancouver

Cui H, Hu Y, Wang ZM, Tan HB, Rong H, Cui H. Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma. Clinical Interventions in Aging. 2013. doi:10.2147/cia.s47350.

BibTeX

@article{hao2013Bonema, title = {Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma}, author = {Hao Cui and Ying Hu and Zin Mei Wang and Hai Bo Tan and Hua Rong and Hong Cui}, journal = {Clinical Interventions in Aging}, year = {2013}, doi = {10.2147/cia.s47350}, }