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Biodemographic Trajectories of Longevity

James W. Vaupel, James R. Carey, Kaare Christensen, Thomas E. Johnson, Anatoli I. Yashin, Niels V. Holm, Ivan A. Iachine, Väinö Kannisto, Aziz A. Khazaeli, Pablo Liedo, Valter D. Longo, Yi Zeng, Kenneth G. Mantón, James W. Curtsinger

Science · 1998 · ▲ 1,050 citations

Dysbiosis Yeast Human
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Abstract

Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights--concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality--offer clues and suggest research on the failure of complicated systems, on new demographic equations for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explication of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.

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OpenAlex
DOI
10.1126/science.280.5365.855
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2026-05-31 MST

Cite this

APA
Vaupel, J.W., Carey, J.R., Christensen, K., Johnson, T.E., Yashin, A.I., Holm, N.V., Iachine, I.A., Kannisto, V., Khazaeli, A.A., Liedo, P., Longo, V.D., Zeng, Y., Mantón, K.G., &amp; Curtsinger, J.W. (1998). Biodemographic Trajectories of Longevity. <em>Science</em>. https://doi.org/10.1126/science.280.5365.855
Vancouver
Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, et al. Biodemographic Trajectories of Longevity. Science. 1998. doi:10.1126/science.280.5365.855.
BibTeX
@article{james1998Biodem, title = {Biodemographic Trajectories of Longevity}, author = {James W. Vaupel and James R. Carey and Kaare Christensen and Thomas E. Johnson and Anatoli I. Yashin and Niels V. Holm and Ivan A. Iachine and Väinö Kannisto and Aziz A. Khazaeli and Pablo Liedo and Valter D. Longo and Yi Zeng and Kenneth G. Mantón and James W. Curtsinger}, journal = {Science}, year = {1998}, doi = {10.1126/science.280.5365.855}, }

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