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An NRF2 Perspective on Stem Cells and Ageing

Matthew B. Dodson, Annadurai Anandhan, Donna D. Zhang, Lalitha Madhavan

Frontiers in Aging · 2021 · ▲ 35 citations

Stem-cell exhaustion Review

Abstract

Redox and metabolic mechanisms lie at the heart of stem cell survival and regenerative activity. NRF2 is a major transcriptional controller of cellular redox and metabolic homeostasis, which has also been implicated in ageing and lifespan regulation. However, NRF2's role in stem cells and their functioning with age is only just emerging. Here, focusing mainly on neural stem cells, which are core to adult brain plasticity and function, we review recent findings that identify NRF2 as a fundamental player in stem cell biology and ageing. We also discuss NRF2-based molecular programs that may govern stem cell state and function with age, and implications of this for age-related pathologies.

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Provenance

Source: OpenAlex
DOI: 10.3389/fragi.2021.690686
Canonical: link ↗
Fetched: 2026-10-06 MST

Cite this

APA

Dodson, M.B., Anandhan, A., Zhang, D.D., & Madhavan, L. (2021). An NRF2 Perspective on Stem Cells and Ageing. <em>Frontiers in Aging</em>. https://doi.org/10.3389/fragi.2021.690686

Vancouver

Dodson MB, Anandhan A, Zhang DD, Madhavan L. An NRF2 Perspective on Stem Cells and Ageing. Frontiers in Aging. 2021. doi:10.3389/fragi.2021.690686.

BibTeX

@article{matthew2021AnNRFP, title = {An NRF2 Perspective on Stem Cells and Ageing}, author = {Matthew B. Dodson and Annadurai Anandhan and Donna D. Zhang and Lalitha Madhavan}, journal = {Frontiers in Aging}, year = {2021}, doi = {10.3389/fragi.2021.690686}, }