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Alzheimer’s disease, dementia, and stem cell therapy

Stem Cell Research & Therapy · 2017 · ▲ 336 citations

Stem-cell exhaustion Stem-cell therapy Human Review

Abstract

Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.

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Provenance

Source: OpenAlex
DOI: 10.1186/s13287-017-0567-5
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Fetched: 2026-06-21 MST

Cite this

APA

Duncan, T., & Valenzuela, M. (2017). Alzheimer’s disease, dementia, and stem cell therapy. <em>Stem Cell Research & Therapy</em>. https://doi.org/10.1186/s13287-017-0567-5

Vancouver

Duncan T, Valenzuela M. Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Research & Therapy. 2017. doi:10.1186/s13287-017-0567-5.

BibTeX

@article{thomas2017Alzhei, title = {Alzheimer’s disease, dementia, and stem cell therapy}, author = {Thomas Duncan and Michael Valenzuela}, journal = {Stem Cell Research & Therapy}, year = {2017}, doi = {10.1186/s13287-017-0567-5}, }