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Alzheimer's disease

Chris Lane, John Hardy, Jonathan M. Schott

European Journal of Neurology · 2017 · ▲ 2,599 citations

Loss of proteostasis Human Preclinical / animal Review

Abstract

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. Finally, the review discusses how our enhanced understanding of Alzheimer pathogenesis, including the recognition of a protracted preclinical phase, is informing new therapeutic strategies with the aim of moving from treatment to prevention.

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Provenance

Source: OpenAlex
DOI: 10.1111/ene.13439
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Fetched: 2026-10-17 MST

Cite this

APA

Lane, C., Hardy, J., & Schott, J.M. (2017). Alzheimer's disease. <em>European Journal of Neurology</em>. https://doi.org/10.1111/ene.13439

Vancouver

Lane C, Hardy J, Schott JM. Alzheimer's disease. European Journal of Neurology. 2017. doi:10.1111/ene.13439.

BibTeX

@article{chris2017Alzhei, title = {Alzheimer's disease}, author = {Chris Lane and John Hardy and Jonathan M. Schott}, journal = {European Journal of Neurology}, year = {2017}, doi = {10.1111/ene.13439}, }