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Alpha‐synuclein RT ‐Qu IC in the CSF of patients with alpha‐synucleinopathies

Graham Fairfoul, Lynne I. McGuire, Suvankar Pal, James W. Ironside, Juliane Neumann, Sharon Christie, Catherine L. Joachim, Margaret M. Esiri, Samuel G. Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade‐Martins, Michele T. M. Hu, Laura Parkkinen

Annals of Clinical and Translational Neurology · 2016 · ▲ 607 citations

Loss of proteostasis Human

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Abstract

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.

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Provenance

Source: OpenAlex
DOI: 10.1002/acn3.338
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Fetched: 2026-10-21 MST

Cite this

APA

Fairfoul, G., McGuire, L.I., Pal, S., Ironside, J.W., Neumann, J., Christie, S., Joachim, C.L., Esiri, M.M., Evetts, S.G., Rolinski, M., Baig, F., Ruffmann, C., Wade‐Martins, R., Hu, M.T.M., Parkkinen, L., & Green, A. (2016). Alpha‐synuclein RT ‐Qu IC in the CSF of patients with alpha‐synucleinopathies. <em>Annals of Clinical and Translational Neurology</em>. https://doi.org/10.1002/acn3.338

Vancouver

Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, et al. Alpha‐synuclein RT ‐Qu IC in the CSF of patients with alpha‐synucleinopathies. Annals of Clinical and Translational Neurology. 2016. doi:10.1002/acn3.338.

BibTeX

@article{graham2016Alphas, title = {Alpha‐synuclein RT ‐Qu IC in the CSF of patients with alpha‐synucleinopathies}, author = {Graham Fairfoul and Lynne I. McGuire and Suvankar Pal and James W. Ironside and Juliane Neumann and Sharon Christie and Catherine L. Joachim and Margaret M. Esiri and Samuel G. Evetts and Michal Rolinski and Fahd Baig and Claudio Ruffmann and Richard Wade‐Martins and Michele T. M. Hu and Laura Parkkinen and A.J.E Green}, journal = {Annals of Clinical and Translational Neurology}, year = {2016}, doi = {10.1002/acn3.338}, }