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Alpha‐synuclein repeat variants and survival in Parkinson's disease

Sun Ju Chung, Joanna M. Biernacka, Sebastian M. Armasu, Kari S. Anderson, Roberta Frigerio, Jan Olav Aasly, Grazia Annesi, Anna Rita Bentivoglio, Laura Brighina, Marie‐Christine Chartier‐Harlin, Stefano Goldwurm, Georgios M. Hadjigeorgiou, Barbara Jasińska‐Myga, Beom Seok Jeon, Yun Joong Kim

Movement Disorders · 2014 · ▲ 14 citations

Dysbiosis Human

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Abstract

OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

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Provenance

Source: OpenAlex
DOI: 10.1002/mds.25841
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Fetched: 2026-10-20 MST

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APA

Chung, S.J., Biernacka, J.M., Armasu, S.M., Anderson, K.S., Frigerio, R., Aasly, J.O., Annesi, G., Bentivoglio, A.R., Brighina, L., Chartier‐Harlin, M., Goldwurm, S., Hadjigeorgiou, G.M., Jasińska‐Myga, B., Jeon, B.S., Kim, Y.J., Krüger, R., Lesage, S., Markopoulou, K., Mellick, G.D., & Morrison, K.E. (2014). Alpha‐synuclein repeat variants and survival in Parkinson's disease. <em>Movement Disorders</em>. https://doi.org/10.1002/mds.25841

Vancouver

Chung SJ, Biernacka JM, Armasu SM, Anderson KS, Frigerio R, Aasly JO, et al. Alpha‐synuclein repeat variants and survival in Parkinson's disease. Movement Disorders. 2014. doi:10.1002/mds.25841.

BibTeX

@article{sun2014Alphas, title = {Alpha‐synuclein repeat variants and survival in Parkinson's disease}, author = {Sun Ju Chung and Joanna M. Biernacka and Sebastian M. Armasu and Kari S. Anderson and Roberta Frigerio and Jan Olav Aasly and Grazia Annesi and Anna Rita Bentivoglio and Laura Brighina and Marie‐Christine Chartier‐Harlin and Stefano Goldwurm and Georgios M. Hadjigeorgiou and Barbara Jasińska‐Myga and Beom Seok Jeon and Yun Joong Kim and Rejko Krüger and Suzanne Lesage and Katerina Markopoulou and George D. Mellick and Karen E. Morrison and Andreas Puschmann and Eng‐King Tan and David Crosiers and Jessie Theuns and Christine Van Broeckhoven}, journal = {Movement Disorders}, year = {2014}, doi = {10.1002/mds.25841}, }