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Alpha‐synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Alex H. Rajput, Carles Vilariño‐Güell, Michele L. Rajput, Owen A. Ross, Alexandra I. Soto‐Ortolaza, Sarah Lincoln, Stephanie A. Cobb, Michael G. Heckman, Matthew James Farrer, Ali H. Rajput

Movement Disorders · 2009 · ▲ 20 citations

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Abstract

Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

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Provenance

Source: OpenAlex
DOI: 10.1002/mds.22795
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Fetched: 2026-10-20 MST

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APA

Rajput, A.H., Vilariño‐Güell, C., Rajput, M.L., Ross, O.A., Soto‐Ortolaza, A.I., Lincoln, S., Cobb, S.A., Heckman, M.G., Farrer, M.J., & Rajput, A.H. (2009). Alpha‐synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. <em>Movement Disorders</em>. https://doi.org/10.1002/mds.22795

Vancouver

Rajput AH, Vilariño‐Güell C, Rajput ML, Ross OA, Soto‐Ortolaza AI, Lincoln S, et al. Alpha‐synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. Movement Disorders. 2009. doi:10.1002/mds.22795.

BibTeX

@article{alex2009Alphas, title = {Alpha‐synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population}, author = {Alex H. Rajput and Carles Vilariño‐Güell and Michele L. Rajput and Owen A. Ross and Alexandra I. Soto‐Ortolaza and Sarah Lincoln and Stephanie A. Cobb and Michael G. Heckman and Matthew James Farrer and Ali H. Rajput}, journal = {Movement Disorders}, year = {2009}, doi = {10.1002/mds.22795}, }