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Ageing with cystic fibrosis: Challenges ahead

Sacha Spelier, Maud I.M. van der Wijst, Isabelle Fajac, D.G. Downey

Journal of Cystic Fibrosis · 2026 · ▲ 1 citations

Chronic inflammation Human Review

Abstract

As life expectancy for people with cystic fibrosis continues to improve due to advances in care and CFTR modulator therapies, age-related comorbidities are emerging as new clinical challenges. This short review summarizes insights from a symposium focusing on ageing and CF at the 20th ECFS Basic Science Conference in March 2025 in Pisa, Italy. Mechanisms of ageing and their involvement in CF disease are first outlined. We then highlight two age-associated comorbidities in CF, cardiovascular disease and colorectal cancer, and outline future research directions to clarify how CF-specific and general ageing mechanisms intersect. Understanding these processes will be crucial for tailoring long-term care strategies in the ageing CF population.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.jcf.2025.12.015
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Fetched: 2026-06-05 MST

Cite this

APA

Spelier, S., Wijst, M.I.V.D., Fajac, I., & Downey, D. (2026). Ageing with cystic fibrosis: Challenges ahead. <em>Journal of Cystic Fibrosis</em>. https://doi.org/10.1016/j.jcf.2025.12.015

Vancouver

Spelier S, Wijst MIVD, Fajac I, Downey D. Ageing with cystic fibrosis: Challenges ahead. Journal of Cystic Fibrosis. 2026. doi:10.1016/j.jcf.2025.12.015.

BibTeX

@article{sacha2026Ageing, title = {Ageing with cystic fibrosis: Challenges ahead}, author = {Sacha Spelier and Maud I.M. van der Wijst and Isabelle Fajac and D.G. Downey}, journal = {Journal of Cystic Fibrosis}, year = {2026}, doi = {10.1016/j.jcf.2025.12.015}, }