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Age-related macular degeneration: Complement in action

Menno van Lookeren Campagne, Erich C. Strauss, Brian L. Yaspan

Immunobiology · 2015 · ▲ 76 citations

Chronic inflammation Human Review

Abstract

The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.imbio.2015.11.007
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Fetched: 2026-10-19 MST

Cite this

APA

Campagne, M.V.L., Strauss, E.C., & Yaspan, B.L. (2015). Age-related macular degeneration: Complement in action. <em>Immunobiology</em>. https://doi.org/10.1016/j.imbio.2015.11.007

Vancouver

Campagne MVL, Strauss EC, Yaspan BL. Age-related macular degeneration: Complement in action. Immunobiology. 2015. doi:10.1016/j.imbio.2015.11.007.

BibTeX

@article{menno2015Agerel, title = {Age-related macular degeneration: Complement in action}, author = {Menno van Lookeren Campagne and Erich C. Strauss and Brian L. Yaspan}, journal = {Immunobiology}, year = {2015}, doi = {10.1016/j.imbio.2015.11.007}, }