Age-Associated Changes in Regional Adiposity and Novel Cardiovascular Risk Factors

Background: \- Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age. Studies suggest that age-related inflammation may affect fatty tissue in the body. If this fat develops in the muscles or around the heart, it may increase risks of heart disease. Researchers will study body composition in older adults to see if age-related changes in body fat are related to higher risks of heart disease. Objectives: \- To study the relationship between fat deposits and aging, and greater risks of heart disease. Eligibility: * Participants in the Baltimore Longitudinal Study of Aging between 50 and 80 years of age. * Individuals between 50 and 80 years of age who have been diagnosed with coronary artery disease. Design: * Participants will be screened with a physical exam and medical history. * Participants will provide blood and urine samples. They will also have their height and weight measured. Waist circumference will also be taken. * Participants will have a DEXA scan to study their muscles. * Participants will have magnetic resonance imaging scans. These scans will study heart function and muscle and blood vessel health. * Participants with coronary artery disease will have catheterization. Blood samples will be collected during the procedure....