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Acid ceramidase promotes senescent cell survival

Rachel Munk, Carlos Anerillas, Martina Rossi, Dimitrios Tsitsipatis, Jennifer L. Martindale, Allison B. Herman, Jen‐Hao Yang, Jackson A. Roberts, Vijay R. Varma, Poonam R. Pandey, Madhav Thambisetty, Myriam Gorospe, Kotb Abdelmohsen

Aging · 2021 · ▲ 30 citations

Cellular senescence Senolytics Cell culture / in vitro

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Abstract

mRNA and a robust increase in ASAH1 protein stability. Furthermore, silencing ASAH1 in pre-senescent fibroblasts decreased the levels of senescence proteins p16, p21, and p53, and reduced the activity of the senescence-associated β-galactosidase. Interestingly, depletion of ASAH1 in pre-senescent cells sensitized these cells to the senolytics Dasatinib and Quercetin (D+Q). Together, our study indicates that ASAH1 promotes senescence, protects senescent cells, and confers resistance against senolytic drugs. Given that inhibiting ASAH1 sensitizes cells towards senolysis, this enzyme represents an attractive therapeutic target in interventions aimed at eliminating senescent cells.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.203170
Canonical: link ↗
Fetched: 2026-06-15 MST

Cite this

APA

Munk, R., Anerillas, C., Rossi, M., Tsitsipatis, D., Martindale, J.L., Herman, A.B., Yang, J., Roberts, J.A., Varma, V.R., Pandey, P.R., Thambisetty, M., Gorospe, M., & Abdelmohsen, K. (2021). Acid ceramidase promotes senescent cell survival. <em>Aging</em>. https://doi.org/10.18632/aging.203170

Vancouver

Munk R, Anerillas C, Rossi M, Tsitsipatis D, Martindale JL, Herman AB, et al. Acid ceramidase promotes senescent cell survival. Aging. 2021. doi:10.18632/aging.203170.

BibTeX

@article{rachel2021Acidce, title = {Acid ceramidase promotes senescent cell survival}, author = {Rachel Munk and Carlos Anerillas and Martina Rossi and Dimitrios Tsitsipatis and Jennifer L. Martindale and Allison B. Herman and Jen‐Hao Yang and Jackson A. Roberts and Vijay R. Varma and Poonam R. Pandey and Madhav Thambisetty and Myriam Gorospe and Kotb Abdelmohsen}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.203170}, }