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Accelerated epigenetic aging in Down syndrome

Steve Horvath, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Stefano Salvioli, Davide Gentilini, Anna Maria Di Blasio, Cristina Giuliani, Spencer Tung, Harry V. Vinters, Claudio Franceschi

Aging Cell · 2015 · ▲ 525 citations

Epigenetic alterations Human

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Abstract

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)).

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Provenance

Source: OpenAlex
DOI: 10.1111/acel.12325
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Fetched: 2026-07-28 MST

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APA

Horvath, S., Garagnani, P., Bacalini, M.G., Pirazzini, C., Salvioli, S., Gentilini, D., Blasio, A.M.D., Giuliani, C., Tung, S., Vinters, H.V., & Franceschi, C. (2015). Accelerated epigenetic aging in Down syndrome. <em>Aging Cell</em>. https://doi.org/10.1111/acel.12325

Vancouver

Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D, et al. Accelerated epigenetic aging in Down syndrome. Aging Cell. 2015. doi:10.1111/acel.12325.

BibTeX

@article{steve2015Accele, title = {Accelerated epigenetic aging in Down syndrome}, author = {Steve Horvath and Paolo Garagnani and Maria Giulia Bacalini and Chiara Pirazzini and Stefano Salvioli and Davide Gentilini and Anna Maria Di Blasio and Cristina Giuliani and Spencer Tung and Harry V. Vinters and Claudio Franceschi}, journal = {Aging Cell}, year = {2015}, doi = {10.1111/acel.12325}, }