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Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency

Bioscience Biotechnology and Biochemistry · 2007 · ▲ 16 citations

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Abstract

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.

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Provenance

Source: OpenAlex
DOI: 10.1271/bbb.70307
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Fetched: 2026-07-15 MST

Cite this

APA

Mutoh, N., & Kitajima, S. (2007). Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency. <em>Bioscience Biotechnology and Biochemistry</em>. https://doi.org/10.1271/bbb.70307

Vancouver

Mutoh N, Kitajima S. Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency. Bioscience Biotechnology and Biochemistry. 2007. doi:10.1271/bbb.70307.

BibTeX

@article{norihiro2007Accele, title = {Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency}, author = {Norihiro Mutoh and Satoko Kitajima}, journal = {Bioscience Biotechnology and Biochemistry}, year = {2007}, doi = {10.1271/bbb.70307}, }