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Ablation of Vacuole Protein Sorting 18 (Vps18) Gene Leads to Neurodegeneration and Impaired Neuronal Migration by Disrupting Multiple Vesicle Transport Pathways to Lysosomes

Chao Peng, Jian Ye, Shunfei Yan, Shanshan Kong, Shen Ye, Chenyu Li, Qinyu Li, Yufang Zheng, Kejing Deng, Tian Xu, Wufan Tao

Journal of Biological Chemistry · 2012 · ▲ 52 citations

Abstract

The physiological function of Vps18 in mammals is unknown. Results: Deleting Vps18 in mice leads to neurodegeneration by disrupting multiple vesicle transport pathways to lysosomes and impairs neuron migration via accumulation of 1 integrin.

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OpenAlex
DOI
10.1074/jbc.m112.384305
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2026-06-05 MST

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APA
Peng, C., Ye, J., Yan, S., Kong, S., Ye, S., Li, C., Li, Q., Zheng, Y., Deng, K., Xu, T., &amp; Tao, W. (2012). Ablation of Vacuole Protein Sorting 18 (Vps18) Gene Leads to Neurodegeneration and Impaired Neuronal Migration by Disrupting Multiple Vesicle Transport Pathways to Lysosomes. <em>Journal of Biological Chemistry</em>. https://doi.org/10.1074/jbc.m112.384305
Vancouver
Peng C, Ye J, Yan S, Kong S, Ye S, Li C, et al. Ablation of Vacuole Protein Sorting 18 (Vps18) Gene Leads to Neurodegeneration and Impaired Neuronal Migration by Disrupting Multiple Vesicle Transport Pathways to Lysosomes. Journal of Biological Chemistry. 2012. doi:10.1074/jbc.m112.384305.
BibTeX
@article{chao2012Ablati, title = {Ablation of Vacuole Protein Sorting 18 (Vps18) Gene Leads to Neurodegeneration and Impaired Neuronal Migration by Disrupting Multiple Vesicle Transport Pathways to Lysosomes}, author = {Chao Peng and Jian Ye and Shunfei Yan and Shanshan Kong and Shen Ye and Chenyu Li and Qinyu Li and Yufang Zheng and Kejing Deng and Tian Xu and Wufan Tao}, journal = {Journal of Biological Chemistry}, year = {2012}, doi = {10.1074/jbc.m112.384305}, }

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