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A transcriptomic atlas of aged human microglia

Marta Olah, Ellis Patrick, Alexandra–Chloé Villani, Jishu Xu, Charles C. White, Katie J. Ryan, Paul Piehowski, Alifiya Kapasi, Parham Nejad, Maria Cimpean, Sarah M. Connor, Christina Yung, Michael Frangieh, Allison McHenry, Wassim Elyaman

Nature Communications · 2018 · ▲ 529 citations

Loss of proteostasis Human

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Abstract

With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts are hindered by the lack of understanding of what constitutes the phenotype of aged human microglia-the cell type that has been strongly implicated by genetic studies in the pathogenesis of age-related neurodegenerative disease. Here, we establish the set of genes that is preferentially expressed by microglia in the aged human brain. This HuMi_Aged gene set captures a unique phenotype, which we confirm at the protein level. Furthermore, we find this gene set to be enriched in susceptibility genes for Alzheimer's disease and multiple sclerosis, to be increased with advancing age, and to be reduced by the protective APOEε2 haplotype. APOEε4 has no effect. These findings confirm the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41467-018-02926-5
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Fetched: 2026-07-28 MST

Cite this

APA

Olah, M., Patrick, E., Villani, A., Xu, J., White, C.C., Ryan, K.J., Piehowski, P., Kapasi, A., Nejad, P., Cimpean, M., Connor, S.M., Yung, C., Frangieh, M., McHenry, A., Elyaman, W., Petyuk, V., Schneider, J.A., Bennett, D.A., Jager, P.L.D., & Bradshaw, E.M. (2018). A transcriptomic atlas of aged human microglia. <em>Nature Communications</em>. https://doi.org/10.1038/s41467-018-02926-5

Vancouver

Olah M, Patrick E, Villani A, Xu J, White CC, Ryan KJ, et al. A transcriptomic atlas of aged human microglia. Nature Communications. 2018. doi:10.1038/s41467-018-02926-5.

BibTeX

@article{marta2018Atrans, title = {A transcriptomic atlas of aged human microglia}, author = {Marta Olah and Ellis Patrick and Alexandra–Chloé Villani and Jishu Xu and Charles C. White and Katie J. Ryan and Paul Piehowski and Alifiya Kapasi and Parham Nejad and Maria Cimpean and Sarah M. Connor and Christina Yung and Michael Frangieh and Allison McHenry and Wassim Elyaman and Vladislav Petyuk and Julie A. Schneider and David A. Bennett and Philip L. De Jager and Elizabeth M. Bradshaw}, journal = {Nature Communications}, year = {2018}, doi = {10.1038/s41467-018-02926-5}, }