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A NAC Gene Regulating Senescence Improves Grain Protein, Zinc, and Iron Content in Wheat

Cristóbal Uauy, Assaf Distelfeld, Tzion Fahima, Ann E. Blechl, Jorge Dubcovsky

Science · 2006 · ▲ 1,588 citations

Cellular senescence Human

Abstract

Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.

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Provenance

Source: OpenAlex
DOI: 10.1126/science.1133649
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Fetched: 2026-05-31 MST

Cite this

APA

Uauy, C., Distelfeld, A., Fahima, T., Blechl, A.E., & Dubcovsky, J. (2006). A NAC Gene Regulating Senescence Improves Grain Protein, Zinc, and Iron Content in Wheat. <em>Science</em>. https://doi.org/10.1126/science.1133649

Vancouver

Uauy C, Distelfeld A, Fahima T, Blechl AE, Dubcovsky J. A NAC Gene Regulating Senescence Improves Grain Protein, Zinc, and Iron Content in Wheat. Science. 2006. doi:10.1126/science.1133649.

BibTeX

@unpublished{cristbal2006ANACGe, title = {A NAC Gene Regulating Senescence Improves Grain Protein, Zinc, and Iron Content in Wheat}, author = {Cristóbal Uauy and Assaf Distelfeld and Tzion Fahima and Ann E. Blechl and Jorge Dubcovsky}, journal = {Science}, year = {2006}, doi = {10.1126/science.1133649}, }