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A harmonized framework for studying exceptional cognitive aging in Latin America.

Crivelli L, Fernandez R, Corvalán N, Sosa AL, Acosta D, Agnoletti G, Surace E, Acosta I, Caramelli P, Aguillón D, Martelli JL, Peñailillo LD, Custodio N, Charamelo A, Damian A

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026

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Abstract

<h4>Introduction</h4>Biological, genetic, and sociocultural factors underlying cognitive resilience and resistance to pathology remain unexplored in Latin America. The Life-Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN-AD) study and Latin American SuperAgers Study (LASAS) establish the first harmonized frameworks to characterize resilience and exceptional cognitive aging phenotypes in the region.<h4>Methods</h4>The shared protocol integrates cognitive, neurological, psychosocial, and genetic data. SuperAgers are deeply phenotyped, while successful cognitive agers are identified through harmonized criteria applied to existing cohorts, ensuring regional adaptation and international comparability. Centralized training and shared procedures ensure cross-site consistency.<h4>Results</h4>We define eligibility criteria and standardized assessments to classify successful cognitive agers and SuperAgers in Latin America and examine biological and psychosocial profiles supporting better-than-expected cognition.<h4>Discussion</h4>LEARN-AD and LASAS represent the first Latin American infrastructure for studying cognitive resilience, resistance, and exceptional cognitive aging, which will generate unprecedented regional databases and grow into larger networks, providing foundations for research, prevention strategies, and precision approaches to promote brain health in Latin America.

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Provenance

Source: Europe PMC
DOI: 10.1002/alz.71373
Canonical: link ↗
Fetched: 2026-07-02 MST

Cite this

APA

L, C., R, F., N, C., AL, S., D, A., G, A., E, S., I, A., P, C., D, A., JL, M., LD, P., N, C., A, C., A, D., JJ, L., R, A., M, P., E, R., & L, I. (2026). A harmonized framework for studying exceptional cognitive aging in Latin America. <em>Alzheimer's & dementia : the journal of the Alzheimer's Association</em>. https://doi.org/10.1002/alz.71373

Vancouver

L C, R F, N C, AL S, D A, G A, et al. A harmonized framework for studying exceptional cognitive aging in Latin America. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. doi:10.1002/alz.71373.

BibTeX

@article{crivelli2026Aharmo, title = {A harmonized framework for studying exceptional cognitive aging in Latin America.}, author = {Crivelli L and Fernandez R and Corvalán N and Sosa AL and Acosta D and Agnoletti G and Surace E and Acosta I and Caramelli P and Aguillón D and Martelli JL and Peñailillo LD and Custodio N and Charamelo A and Damian A and Llibre-Rodriguez JJ and Allegri R and Prina M and Rogalski E and Ibañez L and Llibre-Guerra JJ.}, journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association}, year = {2026}, doi = {10.1002/alz.71373}, }