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A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock

Alexey Moskalev, Svetlana Zhikrivetskaya, George S. Krasnov, Mikhail Shaposhnikov, Ekaterina Proshkina, Dmitry Borisoglebsky, Anton Danilov, Darya Peregudova, I. E. Sharapova, Eugenia Dobrovolskaya, Ilya Solovev, Nadezhda Zemskaya, Lyubov Shilova, Anastasia Snezhkina, Anna V. Kudryavtseva

BMC Genomics · 2015 · ▲ 108 citations

Epigenetic alterations Drosophila
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Abstract

BACKGROUND: The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood. RESULTS: We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C) on an organism's viability indicators (survival and locomotor activity) and transcriptome changes in the Drosophila melanogaster model. All stress factors but cold shock resulted in a decrease of lifespan proportional to the dose of treatment. However, stress-factors affected locomotor activity without correlation with lifespan. Our data revealed both significant similarities and differences in differential gene expression and the activity of biological processes under the influence of stress factors. CONCLUSIONS: Studied doses of stress treatments deleteriously affect the organism's viability and lead to different changes of both general and specific cellular stress response mechanisms.

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OpenAlex
DOI
10.1186/1471-2164-16-s13-s8
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2026-06-30 MST

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APA
Moskalev, A., Zhikrivetskaya, S., Krasnov, G.S., Shaposhnikov, M., Proshkina, E., Borisoglebsky, D., Danilov, A., Peregudova, D., Sharapova, I.E., Dobrovolskaya, E., Solovev, I., Zemskaya, N., Shilova, L., Snezhkina, A., &amp; Kudryavtseva, A.V. (2015). A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. <em>BMC Genomics</em>. https://doi.org/10.1186/1471-2164-16-s13-s8
Vancouver
Moskalev A, Zhikrivetskaya S, Krasnov GS, Shaposhnikov M, Proshkina E, Borisoglebsky D, et al. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. BMC Genomics. 2015. doi:10.1186/1471-2164-16-s13-s8.
BibTeX
@article{alexey2015Acompa, title = {A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock}, author = {Alexey Moskalev and Svetlana Zhikrivetskaya and George S. Krasnov and Mikhail Shaposhnikov and Ekaterina Proshkina and Dmitry Borisoglebsky and Anton Danilov and Darya Peregudova and I. E. Sharapova and Eugenia Dobrovolskaya and Ilya Solovev and Nadezhda Zemskaya and Lyubov Shilova and Anastasia Snezhkina and Anna V. Kudryavtseva}, journal = {BMC Genomics}, year = {2015}, doi = {10.1186/1471-2164-16-s13-s8}, }

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