Evidence brief · intervention
Stem-cell therapy
Synthesized from 10 indexed sources ·
2026-06-03 MST
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
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Sources
- [1] Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
- [2] Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
- [3] Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
- [4] Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration
- [5] Lysosomal Storage Diseases: From Pathophysiology to Therapy
- [6] Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment
- [7] Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging
- [8] Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
- [9] Regenerative Effects of Young Immortalized and Engineered MSC-Derived EVs on Aging and Senescent Brain Models
- [10] Collecting Eggs, Not Killing Chickens: Why Stem Cell Secretome and Exosomes Are Redefining Regenerative Medicine for Healthspan Extension.