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Evidence brief · hallmark

Loss of proteostasis

Synthesized from 10 indexed sources · 2026-07-27 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
  2. [2] The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP)
  3. [3] SCENIC: single-cell regulatory network inference and clustering
  4. [4] Dictionary learning for integrative, multimodal and scalable single-cell analysis
  5. [5] Coming of age: ten years of next-generation sequencing technologies
  6. [6] Head and neck squamous cell carcinoma
  7. [7] Intcal04 Terrestrial Radiocarbon Age Calibration, 0–26 Cal Kyr BP
  8. [8] Parkinson's disease
  9. [9] Oxidative stress and molecular chaperones: a dynamic crosstalk in neurodegenerative disorders
  10. [10] An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease
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