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Evidence brief · hallmark

Loss of proteostasis

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
  2. [2] The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP)
  3. [3] Head and neck squamous cell carcinoma
  4. [4] Intcal04 Terrestrial Radiocarbon Age Calibration, 0–26 Cal Kyr BP
  5. [5] Parkinson's disease
  6. [6] The golden age: gold nanoparticles for biomedicine
  7. [7] The integrated stress response
  8. [8] Decoding ALS: from genes to mechanism
  9. [9] Telomerase and chronic inflammation as central molecular links in aging
  10. [10] Ageing promotes microglial accumulation of slow-degrading synaptic proteins
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