Author
David A. Sinclair
- Indexed works
- 32
- Total citations
- 14,059
- Active years
- 17
Collaborators
Works in the record
Nature 2004
Citation only
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Biochemical Journal 2007
Preprint · OA
Sirtuins in mammals: insights into their biological function
Circulation Research 2012
Open access · OA
The Intersection Between Aging and Cardiovascular Disease
Nature Communications 2013
Open access · OA
Metformin improves healthspan and lifespan in mice
The EMBO Journal 2007
Open access · OA
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
The Journals of Gerontology Series A 2010
Open access · OA
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Nature Reviews Molecular Cell Biology 2016
Preprint · OA
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Cell 2008
Open access · OA
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
Aging Cell 2015
Open access · CC-BY
Interventions to Slow Aging in Humans: Are We Ready?
Circulation Research 2018
Open access · OA
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
European Heart Journal 2015
Open access · CC-BY
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
PLoS Biology 2007
Open access · CC-BY
MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
Nature Reviews Molecular Cell Biology 2007
Citation only
The role of nuclear architecture in genomic instability and ageing
Redox Biology 2019
Open access · CC-BY
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Nature Chemical Biology 2013
Preprint · OA
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
Molecular Microbiology 2004
Open access · OA
MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis
The Annual Review of Pharmacology and Toxicology 2011
Open access · OA
Small-Molecule Allosteric Activators of Sirtuins
Stem Cell Reports 2014
Open access · CC-BY
Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
Aging 2012
Open access · CC-BY
The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction
Ageing Research Reviews 2009
Preprint · OA
The ageing epigenome: Damaged beyond repair?
Aging 2010
Open access · CC-BY
Impact papers on aging in 2009
Nature Aging 2024
Preprint · OA
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction
Methods in molecular biology 2019
Preprint · OA
Molecular and Cellular Characterization of SIRT1 Allosteric Activators
Elsevier eBooks 2010
Citation only
Sirtuins in Aging and Age-Related Diseases
Innovation in Aging 2018
Open access · OA
NAD+ DEPLETION AS A CAUSE OF INFLAMMAGING
Innovation in Aging 2019
Open access · CC-BY
MACHINE LEARNING ANALYSIS OF MOUSE FRAILTY FOR PREDICTION OF BIOLOGICAL AGE AND LIFE EXPECTANCY
The Journals of Gerontology Series A 2025
Open access · CC-BY
Multiomic clocks to predict phenotypic age in mice
bioRxiv (Cold Spring Harbor Laboratory) 2025
Preprint · CC-BY
Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocks
bioRxiv (Cold Spring Harbor Laboratory) 2025
Preprint · OA
Associations Between Frailty and Cognitive Outcomes Across the Lifespan of Mice
SSRN Electronic Journal 2023
Preprint · OA
TIME-Seq Enables Highly-Efficient Epigenetic Age Predictions in Large-Scale Human and Mouse Longevity Studies
Elsevier eBooks 2019
Citation only
Sirtuin Activators
Carolina Digital Repository (University of North Carolina at Chapel Hill) 2020
Preprint · OA