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Tobacco Smoking-Associated Genome-Wide DNA Methylation Changes in the EPIC Study

Srikant Ambatipudi, Cyrille Cuenin, Héctor Hernández‐Vargas, Akram Ghantous, Florence Le Calvez‐Kelm, Rudolf Kaaks, Myrto Barrdahl, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Παγώνα Λάγιου, Androniki Naska, Domenico Palli, Vittorio Krogh, Silvia Polidoro

Epigenomics · 2016 · ▲ 236 citations

Epigenetic alterations

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Abstract

AIM: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. MATERIALS & METHODS: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. RESULTS: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. CONCLUSION: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.

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Provenance

Source: OpenAlex
DOI: 10.2217/epi-2016-0001
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Fetched: 2026-06-09 MST

Cite this

APA

Ambatipudi, S., Cuenin, C., Hernández‐Vargas, H., Ghantous, A., Calvez‐Kelm, F.L., Kaaks, R., Barrdahl, M., Boeing, H., Aleksandrova, K., Trichopoulou, A., Λάγιου, �., Naska, A., Palli, D., Krogh, V., Polidoro, S., Tumino, R., Panico, S., Bueno‐de‐Mesquita, B., Peeters, P.H., & Quirós, J.R. (2016). Tobacco Smoking-Associated Genome-Wide DNA Methylation Changes in the EPIC Study. <em>Epigenomics</em>. https://doi.org/10.2217/epi-2016-0001

Vancouver

Ambatipudi S, Cuenin C, Hernández‐Vargas H, Ghantous A, Calvez‐Kelm FL, Kaaks R, et al. Tobacco Smoking-Associated Genome-Wide DNA Methylation Changes in the EPIC Study. Epigenomics. 2016. doi:10.2217/epi-2016-0001.

BibTeX

@article{srikant2016Tobacc, title = {Tobacco Smoking-Associated Genome-Wide DNA Methylation Changes in the EPIC Study}, author = {Srikant Ambatipudi and Cyrille Cuenin and Héctor Hernández‐Vargas and Akram Ghantous and Florence Le Calvez‐Kelm and Rudolf Kaaks and Myrto Barrdahl and Heiner Boeing and Krasimira Aleksandrova and Antonia Trichopoulou and Παγώνα Λάγιου and Androniki Naska and Domenico Palli and Vittorio Krogh and Silvia Polidoro and Rosario Tumino and Salvatore Panico and Bas Bueno‐de‐Mesquita and Petra H. Peeters and J. Ramón Quirós and Carmen Navarro and Eva Ardanáz and Miren Dorronsoro and Tim Key and Paolo Vineis}, journal = {Epigenomics}, year = {2016}, doi = {10.2217/epi-2016-0001}, }