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The taming of PARP1 and its impact on NAD+ metabolism

Sarah Hurtado-Bagès, G. Knobloch, Andreas G. Ladurner, Marcus Buschbeck

Molecular Metabolism · 2020 · ▲ 98 citations

Genomic instability Epigenetic alterations Review

Abstract

Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. In this review, we discuss how different organelles are linked through NAD+ metabolism and how PARP1 activation in the nucleus can impact the function of distant organelles. We discuss how differentiated cells tame PARP1 function by upregulating an endogenous inhibitor, the histone variant macroH2A1.1. The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD+ homeostasis.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.molmet.2020.01.014
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Fetched: 2026-06-16 MST

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APA

Hurtado-Bagès, S., Knobloch, G., Ladurner, A.G., & Buschbeck, M. (2020). The taming of PARP1 and its impact on NAD+ metabolism. <em>Molecular Metabolism</em>. https://doi.org/10.1016/j.molmet.2020.01.014

Vancouver

Hurtado-Bagès S, Knobloch G, Ladurner AG, Buschbeck M. The taming of PARP1 and its impact on NAD+ metabolism. Molecular Metabolism. 2020. doi:10.1016/j.molmet.2020.01.014.

BibTeX

@article{sarah2020Thetam, title = {The taming of PARP1 and its impact on NAD+ metabolism}, author = {Sarah Hurtado-Bagès and G. Knobloch and Andreas G. Ladurner and Marcus Buschbeck}, journal = {Molecular Metabolism}, year = {2020}, doi = {10.1016/j.molmet.2020.01.014}, }