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The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells

Lisa M. McEwen, Kieran J. O’Donnell, Megan McGill, Rachel D. Edgar, Meaghan J. Jones, Julia L. MacIsaac, David Lin, Katia E. Ramadori, Alexander M. Morin, Nicole Gladish, Elika Garg, Eva Unternäehrer, Irina Pokhvisneva, Neerja Karnani, Michelle Z. L. Kee

Proceedings of the National Academy of Sciences · 2019 · ▲ 297 citations

Epigenetic alterations Human

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Abstract

Significance DNA methylation is the most studied modification in human population epigenetics. Its information content can be explored in 2 principal ways—epigenome-wide association studies and epigenetic age. The latter likely reflects cellular/biological age and works with impressive accuracy across most tissues. In adults, it associates with various environments and health. However, current epigenetic clocks are not very accurate in the pediatric age range perhaps because DNA methylation changes much faster in children. Addressing this crucial gap, we created a precise tool to estimate DNA methylation age specific to pediatric buccal epithelial cells. This tool has the potential to become the standard reference for epigenetic studies broadly relevant to child development across the spectrum from health to disease.

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Provenance

Source: OpenAlex
DOI: 10.1073/pnas.1820843116
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Fetched: 2026-07-28 MST

Cite this

APA

McEwen, L.M., O’Donnell, K.J., McGill, M., Edgar, R.D., Jones, M.J., MacIsaac, J.L., Lin, D., Ramadori, K.E., Morin, A.M., Gladish, N., Garg, E., Unternäehrer, E., Pokhvisneva, I., Karnani, N., Kee, M.Z.L., Klengel, T., Adler, N.E., Barr, R.G., Letourneau, N., & Giesbrecht, G.F. (2019). The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. <em>Proceedings of the National Academy of Sciences</em>. https://doi.org/10.1073/pnas.1820843116

Vancouver

McEwen LM, O’Donnell KJ, McGill M, Edgar RD, Jones MJ, MacIsaac JL, et al. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proceedings of the National Academy of Sciences. 2019. doi:10.1073/pnas.1820843116.

BibTeX

@article{lisa2019ThePed, title = {The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells}, author = {Lisa M. McEwen and Kieran J. O’Donnell and Megan McGill and Rachel D. Edgar and Meaghan J. Jones and Julia L. MacIsaac and David Lin and Katia E. Ramadori and Alexander M. Morin and Nicole Gladish and Elika Garg and Eva Unternäehrer and Irina Pokhvisneva and Neerja Karnani and Michelle Z. L. Kee and Torsten Klengel and Nancy E. Adler and Ronald G. Barr and Nicole Letourneau and Gerald F. Giesbrecht and James N. Reynolds and Darina Czamara and Jeffrey M. Armstrong and Marilyn J. Essex and Carolina de Weerth}, journal = {Proceedings of the National Academy of Sciences}, year = {2019}, doi = {10.1073/pnas.1820843116}, }