Citation only via Europe PMC

The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.

Espeland MA, Semelka CT, Kritchevsky SB, Evans JK, Newman AB.

Diabetes care · 2026

Epigenetic alterations Human

Abstract

The 10-year Action for Health in Diabetes (Look AHEAD) clinical trial compared a multidomain intensive lifestyle intervention to a diabetes support and education program with respect to major cardiovascular disease events (primary outcome) and other diabetes- and obesity-related outcomes. Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.

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Provenance

Source: Europe PMC
DOI: 10.2337/dci25-0126
Canonical: link ↗
Fetched: 2026-07-01 MST

Cite this

APA

MA, E., CT, S., SB, K., JK, E., & AB., N. (2026). The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience. <em>Diabetes care</em>. https://doi.org/10.2337/dci25-0126

Vancouver

MA E, CT S, SB K, JK E, AB. N. The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience. Diabetes care. 2026. doi:10.2337/dci25-0126.

BibTeX

@article{espeland2026TheLoo, title = {The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.}, author = {Espeland MA and Semelka CT and Kritchevsky SB and Evans JK and Newman AB.}, journal = {Diabetes care}, year = {2026}, doi = {10.2337/dci25-0126}, }