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The DNA-dependent protein kinase

Genes & Development · 1999 · ▲ 884 citations

Genomic instability

Abstract

The DNA-dependent protein kinase (DNA–PK) is anuclear serine/threonine protein kinase that is activatedupon association with DNA. Biochemical and geneticdata have revealed DNA–PK to be composed of a largecatalytic subunit, termed DNA–PKcs, and a regulatoryfactor termed Ku. In recent years, mammalian DNA–PKhas been shown to be a crucial component of both theDNA double-strand break (DSB) repair machinery andthe

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Source: OpenAlex
DOI: 10.1101/gad.13.8.916
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Fetched: 2026-06-09 MST

Cite this

APA

Smith, G.C., & Jackson, S.P. (1999). The DNA-dependent protein kinase. <em>Genes & Development</em>. https://doi.org/10.1101/gad.13.8.916

Vancouver

Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes & Development. 1999. doi:10.1101/gad.13.8.916.

BibTeX

@article{graeme1999TheDNA, title = {The DNA-dependent protein kinase}, author = {Graeme C.M. Smith and Stephen P. Jackson}, journal = {Genes & Development}, year = {1999}, doi = {10.1101/gad.13.8.916}, }