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TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

Cold Spring Harbor Perspectives in Biology · 2017 · ▲ 146 citations

Altered intercellular communication

Abstract

Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate and invertebrate models revealed the TGF-β family to be central regulators of tissue morphogenesis. Members of the TGF-β family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-β family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.

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Provenance

Source: OpenAlex
DOI: 10.1101/cshperspect.a022186
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Fetched: 2026-06-11 MST

Cite this

APA

Mullen, A.C., & Wrana, J.L. (2017). TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation. <em>Cold Spring Harbor Perspectives in Biology</em>. https://doi.org/10.1101/cshperspect.a022186

Vancouver

Mullen AC, Wrana JL. TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation. Cold Spring Harbor Perspectives in Biology. 2017. doi:10.1101/cshperspect.a022186.

BibTeX

@article{alan2017TGFFam, title = {TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation}, author = {Alan C. Mullen and Jeffrey L. Wrana}, journal = {Cold Spring Harbor Perspectives in Biology}, year = {2017}, doi = {10.1101/cshperspect.a022186}, }