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Role of mitochondrial dysfunction in Alzheimer's disease

Rudy J. Castellani, Keisuke Hirai, Gjumrakch Aliev, Kelly L. Drew, Akihiko Nunomura, Atsushi Takeda, Ayla Cash, Mark E. Obrenovich, George Perry, Mark A. Smith

Journal of Neuroscience Research · 2002 · ▲ 362 citations

Mitochondrial dysfunction Review

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Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.

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Provenance

Source: OpenAlex
DOI: 10.1002/jnr.10389
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Fetched: 2026-06-10 MST

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APA

Castellani, R.J., Hirai, K., Aliev, G., Drew, K.L., Nunomura, A., Takeda, A., Cash, A., Obrenovich, M.E., Perry, G., & Smith, M.A. (2002). Role of mitochondrial dysfunction in Alzheimer's disease. <em>Journal of Neuroscience Research</em>. https://doi.org/10.1002/jnr.10389

Vancouver

Castellani RJ, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, et al. Role of mitochondrial dysfunction in Alzheimer's disease. Journal of Neuroscience Research. 2002. doi:10.1002/jnr.10389.

BibTeX

@article{rudy2002Roleof, title = {Role of mitochondrial dysfunction in Alzheimer's disease}, author = {Rudy J. Castellani and Keisuke Hirai and Gjumrakch Aliev and Kelly L. Drew and Akihiko Nunomura and Atsushi Takeda and Ayla Cash and Mark E. Obrenovich and George Perry and Mark A. Smith}, journal = {Journal of Neuroscience Research}, year = {2002}, doi = {10.1002/jnr.10389}, }