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Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal, Vítor Teixeira, Tania Medeiros, Rita Vilaça, Pedro Moradas‐Ferreira, Vitor Costa

Microbial Cell · 2014 · ▲ 27 citations

Mitochondrial dysfunction Altered intercellular communication Partial reprogramming (OSK)

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Abstract

Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells – INTRODUCTION Sphingolipids are ubiquitous structural components of eukaryotic cell membranes, and their bioactive metabolites (sphingosine, sphingosine-1-phosphate, ceramide, ceramide-1‑phosphate and lyso-sphingomyelin) are known to act as second messengers in the regulation of signaling pathways ,,,,,. Sphingosine (and related sphingoid bases) and ceramide are involved in the regulation of actin cytoskeleton organization, endocytosis, degradation of nutrient permeases, apoptosis, (...)

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Provenance

Source: OpenAlex
DOI: 10.15698/mic2014.01.121
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Fetched: 2026-07-15 MST

Cite this

APA

Portugal, I.D.B.M.E.C.R.D.C.A.8.4.P., Teixeira, V., Medeiros, T., Vilaça, R., Moradas‐Ferreira, P., & Costa, V. (2014). Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells. <em>Microbial Cell</em>. https://doi.org/10.15698/mic2014.01.121

Vancouver

Portugal IDBMECRDCA84P, Teixeira V, Medeiros T, Vilaça R, Moradas‐Ferreira P, Costa V. Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells. Microbial Cell. 2014. doi:10.15698/mic2014.01.121.

BibTeX

@article{instituto2014Reduce, title = {Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells}, author = {Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal and Vítor Teixeira and Tania Medeiros and Rita Vilaça and Pedro Moradas‐Ferreira and Vitor Costa}, journal = {Microbial Cell}, year = {2014}, doi = {10.15698/mic2014.01.121}, }