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Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

Britny Blumenfeld, Micha Ben‐Zimra, Itamar Simon

International Journal of Molecular Sciences · 2017 · ▲ 46 citations

Genomic instability Review

Abstract

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.

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Provenance

Source: OpenAlex
DOI: 10.3390/ijms18061138
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Fetched: 2026-10-04 MST

Cite this

APA

Blumenfeld, B., Ben‐Zimra, M., & Simon, I. (2017). Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. <em>International Journal of Molecular Sciences</em>. https://doi.org/10.3390/ijms18061138

Vancouver

Blumenfeld B, Ben‐Zimra M, Simon I. Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. International Journal of Molecular Sciences. 2017. doi:10.3390/ijms18061138.

BibTeX

@article{britny2017Pertur, title = {Perturbations in the Replication Program Contribute to Genomic Instability in Cancer}, author = {Britny Blumenfeld and Micha Ben‐Zimra and Itamar Simon}, journal = {International Journal of Molecular Sciences}, year = {2017}, doi = {10.3390/ijms18061138}, }