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Persistent oxidative stress in cancer

Shinya Toyokuni, Keisei Okamoto, Junji Yodoi, Hiroshi Hiai

FEBS Letters · 1995 · ▲ 1,217 citations

Genomic instability

Abstract

DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent normal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.

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Provenance

Source: OpenAlex
DOI: 10.1016/0014-5793(94)01368-b
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Fetched: 2026-08-19 MST

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APA

Toyokuni, S., Okamoto, K., Yodoi, J., & Hiai, H. (1995). Persistent oxidative stress in cancer. <em>FEBS Letters</em>. https://doi.org/10.1016/0014-5793(94)01368-b

Vancouver

Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Letters. 1995. doi:10.1016/0014-5793(94)01368-b.

BibTeX

@article{shinya1995Persis, title = {Persistent oxidative stress in cancer}, author = {Shinya Toyokuni and Keisei Okamoto and Junji Yodoi and Hiroshi Hiai}, journal = {FEBS Letters}, year = {1995}, doi = {10.1016/0014-5793(94)01368-b}, }