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Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease

Hsin‐Jung Ho, Hitoshi Shirakawa

Cells · 2022 · ▲ 218 citations

Abstract

The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative stress and kidney diseases, and revealed new insights into mitochondria-targeted therapeutics for renal injury. Improving mitochondrial homeostasis, increasing mitochondrial biogenesis, and balancing mitochondrial turnover has the potential to protect renal function against oxidative stress. Although there are some reviews that addressed this issue, the articles summarizing the relationship between mitochondria-targeted effects and the risk factors of renal failure are still few. In this review, we integrate recent studies on oxidative stress and mitochondrial function in kidney diseases, especially chronic kidney disease. We organized the causes and risk factors of oxidative stress in the kidneys based in their mitochondria-targeted effects. This review also listed the possible candidates for clinical therapeutics of kidney diseases by modulating mitochondrial function.

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Provenance

Source
OpenAlex
DOI
10.3390/cells12010088
Canonical
link ↗
Fetched
2026-06-12 MST

Cite this

APA
Ho, H., &amp; Shirakawa, H. (2022). Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. <em>Cells</em>. https://doi.org/10.3390/cells12010088
Vancouver
Ho H, Shirakawa H. Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. Cells. 2022. doi:10.3390/cells12010088.
BibTeX
@article{hsinjung2022Oxidat, title = {Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease}, author = {Hsin‐Jung Ho and Hitoshi Shirakawa}, journal = {Cells}, year = {2022}, doi = {10.3390/cells12010088}, }

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