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Neuronal degeneration and mitochondrial dysfunction

Eric A. Schon, Giovanni Manfredi

Journal of Clinical Investigation · 2003 · ▲ 331 citations

Abstract

Parkinson disease (PD); familial Parkinson disease (FPD); Alzheimer disease (AD); familial Alzheimer disease (FAD); amyotrophic lateral sclerosis (ALS); sporadic amyotrophic lateral sclerosis (SALS); oxidative phosphorylation (OXPHOS); reactive oxygen species (ROS); mitochondrial DNA (mtDNA); ribosomal RNA (rRNA); transfer RNA (tRNA); nuclear DNA (nDNA); inner mitochondrial membrane (IMM); intermembrane space (IMS); mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS); myoclonus epilepsy with ragged-red fibers (MERRF); ragged-red fiber (RRF); Kearns-Sayre syndrome (KSS); progressive external ophthalmoplegia (PEO); cytochrome c oxidase (CCO); Leber hereditary optic neuropathy (LHON); Leigh syndrome (LS); Friedreich ataxia (FRDA); mitochondrial superoxide dismutase (Mn-SOD); Cu,Zn-superoxide dismutase (Cu,Zn-SOD); -amyloid peptide (A); progressive supranuclear palsy (PSP); terminal deoxynucleotidyl transferase

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Provenance

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OpenAlex
DOI
10.1172/jci17741
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2026-06-10 MST

Cite this

APA
Schon, E.A., &amp; Manfredi, G. (2003). Neuronal degeneration and mitochondrial dysfunction. <em>Journal of Clinical Investigation</em>. https://doi.org/10.1172/jci17741
Vancouver
Schon EA, Manfredi G. Neuronal degeneration and mitochondrial dysfunction. Journal of Clinical Investigation. 2003. doi:10.1172/jci17741.
BibTeX
@article{eric2003Neuron, title = {Neuronal degeneration and mitochondrial dysfunction}, author = {Eric A. Schon and Giovanni Manfredi}, journal = {Journal of Clinical Investigation}, year = {2003}, doi = {10.1172/jci17741}, }

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